For Research Use Only – Not for Human Consumption. For Research Use Only. Not for Human Consumption. Not for diagnostic, therapeutic or medical use. Statements have not been evaluated by the FDA.
Sermorelin: The Discontinued GHRH Fragment, Explained
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Key points
- A synthetic version of the first 29 amino acids of GHRH.
- Formerly sold as Geref for diagnostic and pediatric use; that product was discontinued.
- No controlled trials support adult wellness or body-composition claims.
What it is
Sermorelin is a laboratory fragment that copies the first 29 amino acids of growth-hormone-releasing hormone (GHRH), the signal the brain sends to the pituitary gland. It weighs roughly 3,358 daltons.
How researchers study it
Experiments focus on the pituitary GHRH receptor and on how the downstream growth-hormone cascade responds. It also serves as a reference point when comparing different GHRH analogs.
What the evidence shows
The approved product's uses were narrow: a diagnostic test of growth hormone and pediatric growth. There are no controlled trials supporting adult wellness or body-composition claims, so the evidence level is low for those purposes.
Regulatory status
No FDA-approved sermorelin product is currently marketed. The earlier approval was for pediatric and diagnostic use, not adult wellness. Today it appears only through compounding, and WADA prohibits it.
