For Research Use Only – Not for Human Consumption. For Research Use Only. Not for Human Consumption. Not for diagnostic, therapeutic or medical use. Statements have not been evaluated by the FDA.
5-Amino-1MQ: A Small Molecule, Not a Peptide
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Key points
- Not a peptide: it is a small molecule that blocks the enzyme NNMT.
- Cell and animal data only; in cells it raises levels of NAD+ and SAM.
- Not FDA-approved for any use.
What it is
5-Amino-1-methylquinolinium is a small organic molecule of about 159 daltons. Even though it is catalogued with peptides, it has no amino acid chain. It is a research tool that blocks nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular metabolism.
How researchers study it
Studies use enzyme-activity assays, fat-cell models and metabolic experiments in rodents. The recurring themes are the NAD salvage pathway and methylation chemistry, because NNMT sits at the crossroads of both.
What the evidence shows
The data are limited to animals and cells. In cells it raises NAD+ and SAM. No completed human trials have been published, so there is no basis for claims about people.
Regulatory status
5-Amino-1MQ is not FDA-approved for any use. It is marketed in the wellness space next to peptides, but it is a different class of compound.
