For Research Use Only – Not for Human Consumption. For Research Use Only. Not for Human Consumption. Not for diagnostic, therapeutic or medical use. Statements have not been evaluated by the FDA.
KPV: A Three-Amino-Acid Fragment Studied in Barrier Models
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Key points
- A fragment of alpha-MSH made of lysine, proline and valine (residues 11-13).
- Evidence is animal and cell only; there are no controlled human data.
- Not FDA-approved for any use.
What it is
KPV is the three-amino-acid sequence Lys-Pro-Val, taken from the tail end of alpha-melanocyte-stimulating hormone (alpha-MSH). It weighs about 342 daltons, which makes it a very small peptide.
How researchers study it
Lab work covers epithelial barrier integrity, mucosal inflammation models and cytokine signaling in cultured cells. These are screening-type systems.
What the evidence shows
Everything published so far is animal or cell-based. No controlled human data exist, so it would be wrong to say anything about effects in people.
Regulatory status
KPV is not FDA-approved for any use. A July 2026 FDA advisory panel gave a favorable, non-binding vote on a compounding question.
